قيس ابراهيم محمد الصغير العوادي

أعضاء هيئة التدريس

قيس ابراهيم محمد الصغير العوادي

أستاذ

كلية العلوم،

قسم الكيمياء

البيانات الشخصية

المؤهلات العلمية

شهادة التأهيل الجامعي
شهادة الدكتوراه اختصاص كيمياء عضوية
ماجستير كيمياء عضوية
الأستاذية

الاهتمامات البحثية

تصنيع الأحماض الأمينية
الإضافة الحلقية 3،1-ثنائية القطبية
توليف الإيزوكسازوليدينات الكيرالية
تصنيع الحلقات الغير متجانسة
https://scholar.google.com/citations?user=x9N7hO4AAAAJ&hl=fr

الأبحاث المنشورة

Untargeted metabolomics approach based on UPLC-ESI-QTOF-MS/MS and evaluation of antioxidant and cytotoxic activities of Nepeta deflersiana Schweinf. ex Hedge supported by molecular modeling and ADMET analysis (2025-01-18)
Exploring the antioxidant potency of novel indolin-2-one-based imidazo-isoxazole hybrids: Design, synthesis and computational studies (2025-10-02)
Anti-ulcer activity of green synthesized selenium nanoparticles using Nigella sativa L. seed extract in rats (2025-11-21)
Synthesis, Structure-Activity Relationship and in silico Studies of Novel Pyrazolothiazole and Thiazolopyridine Derivatives as Prospective Antimicrobial and Anticancer Agents (2021-08-20)
Bioactivities and in silico study of Pergularia tomentosa L. phytochemicals as potent antimicrobial agents targeting type IIA topoisomerase, TyrRS, and Sap1 virulence proteins (2021-01-17)
Design, synthesis ADMET and molecular docking of new imidazo[4,5-b] pyridine-5-thione derivatives as potential tyrosyl-tRNA synthetase inhibitors (2020-09-01)
New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis (2021-02-17)
Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular docking studies (2020-11-05)
Toward a treatment of antibacterial and antifungal infections: Design, synthesis and in vitro activity of novel arylhydrazothiazolylsulfonamides analogues and their insight of DFT, docking and molecular dynamic simulations (2021-06-20)
New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies (2022-01-17)
Novel (2-Oxoindolin-3-ylidene)methyl)-1H-pyrazole and their fused derivatives: Design, synthesis, antimicrobial evaluation, DFT, chemical approach, in silico ADME and molecular docking studies (2022-05-24)
Design, synthesis, in vitro anticancer and antimicrobial evaluation, SAR analysis, molecular docking and dynamic simulation of new pyrazoles, triazoles and pyridazines based isoxazole (2022-05-23)
Effect of the coordination of π-acceptor 4-cyanopyridine ligand on the structural and electronic properties of meso-tetra(para-methoxy) and meso-tetra(para-chlorophenyl) porphyrin cobalt(ii) coordination compounds. Application in the catalytic degradation of methylene blue dye (2020-02-17)
Zinc(ii) triazolemeso-arylsubstituted porphyrins for UV-visible chloride and bromide detection. Adsorption and catalytic degradation of malachite green dye (2020-06-14)
Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papainlike protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies (2022-01-01)
Phytochemical profiling, antimicrobial, antibiofilm, insecticidal, and anti-leishmanial properties of aqueous extract from Juglans regia L. root bark: In vitro and in silico approaches (2023-12-31)
Tripeptides from Allium subhirsitum L. extracts: Pharmacokinetics properties, toxicity prediction and in silico study against SARS-CoV-2 enzymes and pro-inflammatory proteins (2021-01-01)
Repurposing of anisomycin and oleandomycin as a potential anti-(SARS-CoV-2) virus targeting key enzymes using virtual computational approaches (2021-01-01)
Preparation and characterization of ZnO nanoparticles incorporated by mechanical milling into cellulose for electrical insulator applications (2022-04-01)
GC-MS/MS Analysis and Wound Repair Potential of Urtica dioica Essential Oil: In silico Modeling and In vivo Study in Rats (2024-07-05)
LC-ESI/MS-Phytochemical Profiling with Antioxidant, Antibacterial, Antifungal, Antiviral and In Silico Pharmacological Properties of Algerian Asphodelus tenuifolius (Cav.) Organic Extracts (2021-04-01)
Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo Pharmacological Study (2020-10-01)
HR-LCMS-Based Metabolite Profiling, Antioxidant, and Anticancer Properties of Teucrium polium L. Methanolic Extract: Computational and In Vitro Study (2020-11-01)
Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics Simulations (2021-10-01)
Antimicrobial, Antioxidant, Anti-Acetylcholinesterase, Antidiabetic, and Pharmacokinetic Properties of Carum carvi L. and Coriandrum sativum L. Essential Oils Alone and in Combination (2021-06-01)
Lapachol and (α/β)-Lapachone as Inhibitors of SARS-CoV-2 Main Protease (Mpro) and hACE-2: ADME Properties, Docking and Dynamic Simulation Approaches (2022-07-01)
Optical and photoelectronic properties of a new material: Optoelectronic application (2020-01-01)
Antioxidant Activities of a New Chemotype of Piper cubeba L. Fruit Essential Oil (Methyleugenol/Eugenol): In Silico Molecular Docking and ADMET Studies (2020-11-01)
Antimicrobial, Antioxidant, Anti-Acetylcholinesterase, Antidiabetic, and Pharmacokinetic Properties of Carum carvi L. and Coriandrum sativum L. Essential Oils … (2021-01-01)
Antioxidant Activities of a New Chemotype of Piper cubeba L. Fruit Essential Oil (Methyleugenol/Eugenol): In Silico Molecular Docking and ADMET Studies (2020-01-01)
Tomatidine and patchouli alcohol as inhibitors of SARS-CoV-2 enzymes (3CLpro, PLpro and NSP15) by molecular docking and molecular dynamics simulations (2021-01-01)
Toward a treatment of antibacterial and antifungal infections: Design, synthesis and in vitro activity of novel arylhydrazothiazolylsulfonamides analogues and their insight of … (2021-01-01)
Synthesis, in vitro antimicrobial assessment, and computational investigation of pharmacokinetic and bioactivity properties of novel trifluoromethylated compounds using in … (2020-01-01)
In vitro antimicrobial and α-glucosidase inhibitory potential of enantiopure cycloalkylglycine derivatives: Insights into their in silico pharmacokinetic, druglikeness, and … (2020-01-01)
HR-LCMS-Based Metabolite Profiling, Antioxidant, and Anticancer Properties of Teucrium polium L. Methanolic Extract: Computational and In Vitro Study (2020-01-01)
Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of identified inhibitor (2008-01-01)
Design, synthesis, in vitro anticancer and antimicrobial evaluation, SAR analysis, molecular docking and dynamic simulation of new pyrazoles, triazoles and pyridazines based … (2022-01-01)
Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo … (2020-01-01)
Design, synthesis, molecular properties and in vitro antioxidant and antibacterial potential of novel enantiopure isoxazolidine derivatives (2020-01-01)
Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular docking studies (2020-01-01)
Synthesis, structure‐activity relationship and in silico studies of novel pyrazolothiazole and thiazolopyridine derivatives as prospective antimicrobial and anticancer agents (2021-01-01)
Inhibition of HSP90 with Pochoximes: SAR and Structure‐Based Insights (2009-01-01)
Design, synthesis, biological evaluation and in silico studies of novel 1, 2, 3-triazole linked benzoxazine-2, 4-dione conjugates as potent antimicrobial, antioxidant and anti … (2022-01-01)
Stereoselective synthesis of enantiopure N-substituted pyrrolidin-2, 5-dione derivatives by 1, 3-dipolar cycloaddition and assessment of their in vitro antioxidant and … (2017-01-01)
Multifunctional isoxazolidine derivatives as α-amylase and α-glucosidase inhibitors (2020-01-01)
Design, synthesis ADMET and molecular docking of new imidazo[4,5-b]pyridine-5-thione derivatives as potential tyrosyl-tRNA synthetase inhibitors (2020-01-01)
Effect of the coordination of π-acceptor 4-cyanopyridine ligand on the structural and electronic properties of meso-tetra (para-methoxy) and meso-tetra (para-chlorophenyl … (2020-01-01)
GC/MS Profiling, Antibacterial, Anti-Quorum Sensing, and Antibiofilm Properties of Anethum graveolens L. Essential Oil: Molecular Docking Study and In-Silico … (2023-01-01)
GC-MS Profiling, Vibriocidal, Antioxidant, Antibiofilm, and Anti-Quorum Sensing Properties of Carum carvi L. Essential Oil: In Vitro and In Silico Approaches (2022-01-01)
1, 3-Dipolar cycloaddition of a chiral nitrone to (E)-1, 4-dichloro-2-butene: a new efficient synthesis of (2S, 3S, 4R)-4-hydroxyisoleucine (2012-01-01)
New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure … (2021-01-01)
Novel enantiopure isoxazolidine and C-alkyl imine oxide derivatives as potential hypoglycemic agents: Design, synthesis, dual inhibitors of α-amylase and α-glucosidase, ADMET … (2020-01-01)
Analogues of insulin secretagogue (2S, 3R, 4S)-4-hydroxyisoleucine: synthesis by 1, 3-dipolar cycloaddition reactions of chiral nitrones to alkenes (2008-01-01)
HPLC/MS Phytochemical Profiling with Antioxidant Activities of Echium humile Desf. Extracts: ADMET Prediction and Computational Study Targeting Human … (2021-01-01)
Unprecedented stereoselective synthesis of 3-methylisoxazolidine-5-aryl-1, 2, 4-oxadiazoles via 1, 3-dipolar cycloaddition and study of their in vitro antioxidant activity (2016-01-01)
Cycloadditions of chiral nitrones to racemic 3-substituted butenes: a direct access with kinetic resolution to enantiopure dihydroxylated amino acids (2006-01-01)
Multifunctional derivatives of spiropyrrolidine tethered indeno-quinoxaline heterocyclic hybrids as potent antimicrobial, antioxidant and antidiabetic agents: design, synthesis … (2022-01-01)
In Vitro and In Silico Screening of Anti-Vibrio spp., Antibiofilm, Antioxidant and Anti-Quorum Sensing Activities of Cuminum cyminum L. Volatile Oil (2022-01-01)
Lc-esi/ms-phytochemical profiling with antioxidant, antibacterial, antifungal, antiviral and in silico pharmacological properties of algerian asphodelus tenuifolius (cav … (2021-01-01)
Cycloaddition of a chiral nitrone to allylic motifs: an access to enantiopure sugar-based amino acids displaying a stable glycosidic bond and to 4 (S)-4-hydroxy-L-ornithine (2012-01-01)
Phytochemical Profiling of Allium subhirsutum L. Aqueous Extract with Antioxidant, Antimicrobial, Antibiofilm, and Anti-Quorum Sensing Properties: In Vitro and In … (2022-01-01)
Bioactivities and in silico study of Pergularia tomentosa L. phytochemicals as potent antimicrobial agents targeting type IIA topoisomerase, TyrRS, and Sap1 … (2021-01-01)
Zinc(ii) triazole meso-arylsubstituted porphyrins for UV-visible chloride and bromide detection. Adsorption and catalytic degradation of malachite green dye (2020-01-01)
New synthetic routes toward enantiopure (2S, 3R, 4R)-4-hydroxyisoleucine by 1, 3-dipolar cycloaddition of a chiral nitrone to C4 alkenes (2007-01-01)
In vitro and in silico evaluation of antiproliferative activity of new isoxazolidine derivatives targeting EGFR: design, synthesis, cell cycle analysis, and apoptotic inducers (2023-01-01)
In silico design, synthesis, and evaluation of novel enantiopure isoxazolidines as promising dual inhibitors of α-amylase and α-glucosidase (2024-01-01)
Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies (2022-01-01)
Identification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: design, synthesis, in vitro and multiscale molecular modeling approaches (2024-01-01)
Phytochemical profiling, antimicrobial, antibiofilm, insecticidal, and anti-leishmanial properties of aqueous extract from Juglans regia L. root bark: In vitro and in silico … (2023-01-01)
GC-MS/MS Analysis and Wound Repair Potential of Urtica dioica Essential Oil: In silico Modeling and In vivo Study in Rats (2025-01-01)
Synthesis, optical properties, DNA, β-cyclodextrin interaction, hydrogen isotope sensor and computational study of new enantiopure isoxazolidine derivative (ISoXD) (2024-01-01)
New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and … (2022-01-01)
HPLC-MS Profiling, Antioxidant, Antimicrobial, Antidiabetic, and Cytotoxicity Activities of Arthrocnemum indicum (Willd.) Moq. Extracts (2022-01-01)
Biological activities evaluation of enantiopure isoxazolidine derivatives: In vitro, in vivo and in silico studies (2019-01-01)
Novel (2-Oxoindolin-3-ylidene) methyl)-1H-pyrazole and their fused derivatives: Design, synthesis, antimicrobial evaluation, DFT, chemical approach, in silico ADME and … (2022-01-01)
Synthesis of new porphyrin complexes: Evaluations on optical, electrochemical, electronic properties and application as an optical sensor (2019-01-01)
Stereoselective synthesis of 1, 2, 3-triazolyl-functionalized isoxazolidines, via two consecutive 1, 3-dipolar cycloadditions, as precursors of unnatural amino acids (2013-01-01)
A reversible optical sensor film for mercury ions discrimination based on isoxazolidine derivative and exhibiting pH sensing (2022-01-01)
Phytochemical Profiling, Antimicrobial and α-Glucosidase Inhibitory Potential of Phenolic-Enriched Extracts of the Aerial Parts from Echium humile Desf.: In Vitro … (2022-01-01)
X-ray molecular structure characterization of a hexamethylenetetramine zinc (II) porphyrin complex, catalytic degradation of toluidine blue dye, experimental and statistical … (2021-01-01)
Synthesis and SPAR exploration of new semicarbazone-triazole hybrids in search of potent antioxidant, antibacterial and antifungal agents (2019-01-01)
Design, synthesis, biological evaluation, kinetic studies and molecular modeling of imidazo-isoxazole derivatives targeting both α-amylase and α-glucosidase inhibitors (2024-01-01)
GC-MS profile, α-glucosidase inhibition potential, antibacterial and antioxidant evaluation of peels Citrus aurantium (L.), essential oil (2021-01-01)
Novel routes to either racemic or enantiopure α-amino-(4-hydroxy-pyrrolidin-3-yl) acetic acid derivatives and biological evaluation of a new promising pharmacological scaffold (2015-01-01)
Synthesis, optical properties, DNA, β-cyclodextrin interactions, and antioxidant evaluation of novel isoxazolidine derivative (ISoXD2): A multispectral and computational analysis (2024-01-01)
Multi‐Step Synthesis and Biological Evaluation of Analogues of Insulin Secretagogue (2S,3R,4S)‐4‐Hydroxyisoleucine (2009-01-01)
Lapachol and (α/β)-lapachone as inhibitors of SARS-CoV-2 Main Protease (Mpro) and hACE-2: ADME properties, docking and dynamic simulation approaches (2022-01-01)
Tripeptides from Allium subhirsitum L. extracts: Pharmacokinetics properties, toxicity prediction and in silico study against SARS-CoV-2 enzymes and pro-inflammatory proteins (2021-01-01)
Unexpected synthesis of aziridines under Cu (I) catalyzed Kinugasa conditions assisted by microwave irradiation (2016-01-01)
Stereoselective Synthesis of Enantiopure Cycloalkylglycines by 1, 3‐Dipolar Cycloaddition of a Chiral Nitrone to Cycloalkenes (2014-01-01)
A Cycloaddition–Cyclization Combined Approach to Enantiopure 3‐Glycinyl‐4‐hydroxypyrrolidines and 3‐Substituted 4‐Hydroxyprolines (2014-01-01)
Repurposing of anisomycin and oleandomycin as a potential anti-(SARS-CoV-2) virus targeting key enzymes using virtual computational approaches (2022-01-01)
Synthesis of some isoxazolidine and isoxazoline derivatives using nitrone-derived (-)-menthone via 1, 3-dipolar cycloaddition with alkenes, alkynes and cycloalkenes (2016-01-01)
Untargeted metabolomics approach based on UPLC-ESI-QTOF-MS/MS and evaluation of antioxidant and cytotoxic activities of Nepeta deflersiana Schweinf. ex Hedge supported by … (2025-01-01)
A stereoselective method for the synthesis of enantiopure 3-substituted 4-hydroxyproline derivatives via 1, 3-dipolar cycloadditions (2016-01-01)
C-glycosyl amino-substituted hydro-and benzoquinones: Synthesis and preliminary biological evaluation (2007-01-01)
Synthesis of Semicyclic Dienes by Modified Julia Olefination of Vinyl Sulfones Derived from Carbohydrates (2007-01-01)
Fatty acid profiling and bioactive potential of date palm (Phoenix dactylifera) seed oil: antioxidant, antimicrobial, and α-glucosidase inhibitory activities (2025-01-01)
Synthesis, Molecular Docking and Anticancer Activity of New Substituted Pyridine-1, 2, 3-Triazole Hybrid N-Glycosides Via Click Chemistry (2024-01-01)
Optical and photoelectronic properties of a new material: Optoelectronic application (2020-01-01)
Unprecedented Synthesis of 4‐Ylidene (3 S)‐3‐hydroxy‐1‐aryl (alkyl)‐pyrrolidine‐2, 5‐diones Based on 1, 3‐Dipolar Cycloaddition of a Sugar‐derived Nitrone to N‐Substituted … (2019-01-01)
Evaluation of Antioxidant, Anti-inflammatory, Anti-hemolytic, and Enzyme Inhibitory Activities of Polysaccharide Derived from Opuntia stricta (Haw.) Haw. Pulp and … (2025-01-01)
Antioxidant and antimicrobial activities of Thymus vulgaris L. essential oil growing wild in Tunisia (2021-01-01)
Anti-ulcer activity of green synthesized selenium nanoparticles using Nigella sativa L. seed extract in rats (2025-01-01)
Comprehensive multispectral and computational study of isoxazolidine derivative ‘ISoXD3’: Synthesis, spectral characteristics, DNA binding, and comparative effects of allyl and … (2025-01-01)
Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties (2023-01-01)
Mechanochemical Promoted Heterocycles: A Solvent-free Route to Triazole Carbohydrates as Glycogen Phosphorylase Inhibitors (2022-01-01)
Unprecedented 3-O-methyl-3-C-trifluoromethyl-d-ribono-(and l-lyxono)-γ-lactones synthesized by nucleophilic trifluoromethylation of d-hexose-derived cyclic ketones (2016-01-01)
Study of the Regio-and Stereoselectivity of [3+ 2] Cycloaddition of Nitrile Oxides to Various Racemic 3-acyloxy and 3-hydroxybut-1-enes (2012-01-01)
Synthesis of Novel Thiosemicarbazones and Their Molecular Docking Simulations as Inhibitors of α-Amylase and α-Glycosidase Enzymes (2025-01-01)
Exploring the antioxidant potency of novel indolin-2-one-based imidazo-isoxazole hybrids: Design, synthesis and computational studies (2025-01-01)
Exploring 1, 3-dipolar cycloaddition reactions of nitrones with alkenes: Synthesis of isoxazolidine derivatives (2025-01-01)
Design, Characterization and Molecular Docking Study of the New Isoxazolidine-1, 2, 3-Triazole Hybrids (2024-01-01)
S. Ghannay Synthesis of (3S, 3aS, 6aS)-2-acetyl-N-methylhexahydrofuro [3, 4-d][1, 2] oxazole-3-carboxamide via an oxidative cleavage using m-CPBA. ADME approach: Ghannay et al (2022-01-01)
Synthesis and characterization of novel isoxazolidine-thiosemicarbazone hybrid derivatives as precursor of unnatural amino acids (2022-01-01)
Crystal structure of (1S, 2S, 2′ R, 3a′ S, 5R)-2′-[(5-bromo-1H-indol-3-yl) methyl]-2-isopropyl-5, 5′-dimethyldihydro-2′ H-spiro [cyclohexane-1, 6′-imidazo [1, 5-b … (2016-01-01)
Crystal structure of 5-chloromethyl-N-methyl-4-[(4-phenyl-1, 2, 3-triazol-1-yl) methyl] isoxazolidine-3-carboxamide (2016-01-01)
(1S, 2R, 2′ S, 3′ aS, 5R)-2′-[(1S)-1-Hydroxyethyl]-2-isopropyl-5, 5′-dimethyl-3′, 3′ a-dihydro-2′ H-spiro [cyclohexane-1, 6′-imidazo [1, 5-b] isoxazol]-4′(5′ H)-one (2007-01-01)
Interaction Studies of a Novel Enantiopure Isoxazolidine with DNA and β-Cyclodextrin: Binding and Antioxidant Properties (2026-01-01)
Neuroprotective effects of Artemisia campestris essential oil against chlorpyrifos-induced toxicity in rats supported by computational modelling (2025-01-01)
Protective effect of Arthrocnemum indicum ethanolic extract on hypercholesterolemic rats along with antioxidant and antimicrobial activities (2025-01-01)
. Click Chemistry: a promising approach for 1, 2, 3-triazole synthesis (2024-01-01)
Synthesis of New 1, 2, 3-Triazole Glycosides-Based Quinoline System via Click Cycloaddition (2023-01-01)
Preparation and characterization of ZnO nanoparticles incorporated by mechanical milling into cellulose for electrical insulator applications (2022-01-01)
Synthesis of (3S,3aS,6aS)-2-acetyl-N-methylhexahydrofuro[3,4- d][1,2]oxazole-3-carboxamide via an oxidative cleavage using m-CPBA. ADME approach (2022-01-01)
Thymus vulgaris L. Essential Oil: Effect on Fatty Acids and Proteins Oxidation of Little Tuna (Euthynnus alletteratus) Minced during Refrigerated Storage (2021-01-01)
Recueil du Premier Colloque Maghrébin sur la Chimie des Hétérocycles: CMCH 1-2017 organisé les 16 & 17 Mai 2017 par l'Association Tunisienne de Chimie Hétérocyclique et ses … (2020-01-01)
Iconographies supplémentaires de l'article: A stereoselective method for the synthesis of enantiopure 3-substituted 4-hydroxyproline derivatives via 1, 3-dipolar cycloadditions (2016-01-01)
Crystal structure of 2-isopropyl-5, 7′-dimethyl-1′, 3′, 3a', 6′, 8a', 8b'-hexahydrospiro [cyclohexane-1, 6′-furo [3, 4-d] imidazo [1, 5-b] isoxazol]-8′(7′ H)-one (2016-01-01)
Pyrrolidine derivatives (2015-01-01)
Novel pyrrolidine derivatives (2015-01-01)
Synthèse d'analogues de la 4-hydroxyisoleucine, un hypoglycémiant naturel (2006-01-01)
Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties (2023-01-01)
Synthesis and SPAR exploration of new semicarbazone-triazole hybrids in search of potent antioxidant, antibacterial and antifungal agents (2019-02-01)
Biological Activities Evaluation of Enantiopure Isoxazolidine Derivatives: In Vitro, In Vivo and In Silico Studies (2019-03-01)
Synthesis of New Porphyrin Complexes: Evaluations on Optical, Electrochemical, Electronic Properties and Application as an Optical Sensor (2019-01-31)
SYNTHESIS OF SOME ISOXAZOLIDINE AND ISOXAZOLINE DERIVATIVES USING NITRONE-DERIVED (-)-MENTHONE VIA 1,3-DIPOLAR CYCLOADDITION WITH ALKENES, ALKYNES AND CYCLOALKENES (2016-11-01)
A stereoselective method for the synthesis of enantiopure 3-substituted 4-hydroxyproline derivatives via 1,3-dipolar cycloadditions (2016-08-01)
Unexpected synthesis of aziridines under Cu(I) catalyzed Kinugasa conditions assisted by microwave irradiation (2016-03-01)
Novel routes to either racemic or enantiopure α-amino-(4-hydroxy-pyrrolidin-3-yl)acetic acid derivatives and biological evaluation of a new promising pharmacological scaffold (2015-06-15)
Stereoselective Synthesis of Enantiopure Cycloalkylglycines by 1,3-Dipolar Cycloaddition of a Chiral Nitrone to Cycloalkenes (2014-09-01)
A Cycloaddition-Cyclization Combined Approach to Enantiopure 3-Glycinyl-4-hydroxypyrrolidines and 3-Substituted 4-Hydroxyprolines (2014-07-01)
Stereoselective synthesis of 1,2,3-triazolyl-functionalized isoxazolidines, via two consecutive 1,3-dipolar cycloadditions, as precursors of unnatural amino acids (2013-04-10)
1,3-Dipolar cycloaddition of a chiral nitrone to (E)-1,4-dichloro-2-butene: a new efficient synthesis of (2S,3S,4R)-4-hydroxyisoleucine (2012-06-06)
Cycloaddition of a chiral nitrone to allylic motifs: an access to enantiopure sugar-based amino acids displaying a stable glycosidic bond and to 4(S)-4-hydroxy-L-ornithine (2012-02-11)
Study of the Regio- and Stereoselectivity of [3+2] Cycloaddition of Nitrile Oxides to Various Racemic 3-acyloxy and 3-hydroxybut-1-enes (2012-02-01)
Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights (2009-11-23)
Multi-Step Synthesis and Biological Evaluation of Analogues of Insulin Secretagogue (2S,3R,4S)-4-Hydroxyisoleucine (2009-01-01)
Analogues of insulin secretagogue (2S,3R,4S)-4-hydroxyisoleucine:: synthesis by 1,3-dipolar cycloaddition reactions of chiral nitrones to alkenes (2008-05-16)
Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor (2008-01-01)
C-glycosyl amino-substituted hydro- and benzoquinones:: Synthesis and preliminary biological evaluation (2007-11-16)
New synthetic routes toward enantiopure (2S,3R,4R)-4-hydroxyisoleucine by 1,3-dipolar cycloaddition of a chiral nitrone to C4 alkenes (2007-11-02)
Synthesis of semicyclic dienes by modified julia olefination of vinyl Sulfones derived from carbohydrates (2007-10-01)
(1S, 2R, 2′S, 3′aS,5R)-2′-[(1R)-1-hydroxyethyl]-2-isopropyl-5,5′-dimethyl-3′,3′a-dihydro-2′H-spiro[cyclohexane-1,6′-imidazo[1,5-b]isoxazol]4′(5′H)-one (2007-03-01)
1S, 2R, 2′S, 3′aS, 5R)-2′-[(1S)-1-hydroxyethyl]-2-isopropyl-5,5′-dimethyl-3′,3′a-dihydro-2′H-spiro[cyclohexane-1,6′-imidazo[1,5-b]isoxazol]-4′(5′H)-one (2007-03-01)
Cycloadditions of chiral nitrones to racemic 3-substituted butenes: A direct access with kinetic resolution to enantiopure dihydroxylated amino acids (2006-12-01)
Design, synthesis, biological evaluation, kinetic studies and molecular modeling of imidazo-isoxazole derivatives targeting both α-amylase and α-glucosidase inhibitors (2024-10-12)
Synthesis, optical properties, DNA, β-cyclodextrin interaction, hydrogen isotope sensor and computational study of new enantiopure isoxazolidine derivative (ISoXD) (2024-02-17)
Identification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: Design, synthesis, in vitro and multiscale molecular modeling approaches (2024-02-13)
In Silico Design, Synthesis, and Evaluation of Novel Enantiopure Isoxazolidines as Promising Dual Inhibitors of α-Amylase and α-Glucosidase (2024-01-01)
In Vitro and In Silico Evaluation of Antiproliferative Activity of New Isoxazolidine Derivatives Targeting EGFR: Design, Synthesis, Cell Cycle Analysis, and Apoptotic Inducers (2023-07-01)
Synthesis, optical properties, DNA, β-cyclodextrin interactions, and antioxidant evaluation of novel isoxazolidine derivative (ISoXD2): A multispectral and computational analysis (2024-07-16)
A Reversible Optical Sensor Film for Mercury Ions Discrimination Based on Isoxazolidine Derivative and Exhibiting pH Sensing (2022-11-01)
Design, synthesis, biological evaluation and in silico studies of novel 1,2,3- triazole linked benzoxazine-2,4-dione conjugates as potent antimicrobial, antioxidant and anti- inflammatory agents (vol 15, 104226, 2022) (2023-06-15)
Design, synthesis, biological evaluation and in silico studies of novel 1,2,3-triazole linked benzoxazine-2,4-dione conjugates as potent antimicrobial, antioxidant and anti-inflammatory agents (2022-09-11)
Multifunctional isoxazolidine derivatives as α-amylase and α-glucosidase inhibitors (2020-05-01)
Unprecedented Synthesis of 4-Ylidene (3 S)-3-hydroxy-1-aryl (alkyl)-pyrrolidine-2,5-diones Based on 1,3-Dipolar Cycloaddition of a Sugar-derived Nitrone to N-Substituted Maleimides (2019-05-24)
GC/MS Profiling, Antibacterial, Anti-Quorum Sensing, and Antibiofilm Properties of Anethum graveolens L. Essential Oil: Molecular Docking Study and In-Silico ADME Profiling (2023-05-16)
Multifunctional Derivatives of Spiropyrrolidine Tethered Indeno-Quinoxaline Heterocyclic Hybrids as Potent Antimicrobial, Antioxidant and Antidiabetic Agents: Design, Synthesis, In Vitro and In Silico Approaches (2022-11-01)
In Vitro and In Silico Screening of Anti-Vibrio spp., Antibiofilm, Antioxidant and Anti-Quorum Sensing Activities of Cuminum cyminum L. Volatile Oil (2022-09-01)
Phytochemical Profiling, Antimicrobial and α-Glucosidase Inhibitory Potential of Phenolic-Enriched Extracts of the Aerial Parts from Echium humile Desf.: In Vitro Combined with In Silico Approach (2022-05-01)
GC-MS Profiling, Vibriocidal, Antioxidant, Antibiofilm, and Anti-Quorum Sensing Properties of Carum carvi L. Essential Oil: In Vitro and In Silico Approaches (2022-04-01)
Phytochemical Profiling of Allium subhirsutum L. Aqueous Extract with Antioxidant, Antimicrobial, Antibiofilm, and Anti-Quorum Sensing Properties: In Vitro and In Silico Studies (2022-02-01)
HPLC-MS Profiling, Antioxidant, Antimicrobial, Antidiabetic, and Cytotoxicity Activities of Arthrocnemum indicum (Willd.) Moq. Extracts (2022-01-01)
HPLC/MS Phytochemical Profiling with Antioxidant Activities of Echium humile Desf. Extracts: ADMET Prediction and Computational Study Targeting Human Peroxiredoxin 5 Receptor (2021-11-01)
Novel enantiopure isoxazolidine and C-alkyl imine oxide derivatives as potential hypoglycemic agents: Design, synthesis, dual inhibitors of α-amylase and α-glucosidase, ADMET and molecular docking study (2020-11-01)
Design, synthesis, molecular properties and in vitro antioxidant and antibacterial potential of novel enantiopure isoxazolidine derivatives (2020-01-01)
Stereoselective synthesis of enantiopure N-substituted pyrrolidin-2,5-dione derivatives by 1,3-dipolar cycloaddition and assessment of their in vitro antioxidant and antibacterial activities (2017-06-01)
Unprecedented stereoselective synthesis of 3-methylisoxazolidine-5-aryl-1,2,4-oxadiazoles via 1,3-dipolar cycloaddition and study of their in vitro antioxidant activity (2016-01-01)
Unprecedented 3-O-methyl-3-C-trifluoromethyl-D-ribono- (and L-lyxono)-γ-lactones synthesized by nucleophilic trifluoromethylation of D-hexose-derived cyclic ketones (2016-06-01)
Advanced Synthetic Strategies and Therapeutic Applications of Nitrogen Heterocyclic Compounds (2026-01-01)
Synthesis, Photophysical and Docking Studies of a Novel Isoxazolidine–Benzimidazole Hybrid and Preliminary Cytotoxic Evaluation: Binding Interactions with DNA and β-Cyclodextrin (2026-01-01)
From surface engineering to targeted nanomedicine: the evolving role of gold nanoparticle (2026-01-01)
Synthesis, photophysical and docking studies of a novel isoxazolidine-benzimidazole hybrid and preliminary cytotoxic evaluation: Binding interactions with DNA and β-cyclodextrin (2026-12-15)
Exploring the antioxidant potency of novel indolin-2-one-based imidazo-isoxazole hybrids: Design, synthesis and computational studies (2026-02-05)
Neuroprotective effects of Artemisia campestris essential oil against chlorpyrifos-induced toxicity in rats supported by computational modelling (2026-01-01)
Evaluation of Antioxidant, Anti-inflammatory, Anti-hemolytic, and Enzyme Inhibitory Activities of Polysaccharide Derived from Opuntia stricta (Haw.) Haw. Pulp and its Effects on Wound Healing in Diabetic Rats (2025-12-01)
Untargeted metabolomics approach based on UPLC-ESI-QTOF-MS/MS and evaluation of antioxidant and cytotoxic activities of Nepeta deflersiana Schweinf. ex Hedge supported by molecular modeling and ADMET analysis (2025-06-25)
Protective effect of Arthrocnemum indicum ethanolic extract on hypercholesterolemic rats along with antioxidant and antimicrobial activities (2025-06-01)
Fatty acid profiling and bioactive potential of date palm (Phoenix dactylifera) seed oil: antioxidant, antimicrobial, and α-glucosidase inhibitory activities (2025-04-01)
Comprehensive multispectral and computational study of isoxazolidine derivative ‘ISoXD3’: Synthesis, spectral characteristics, DNA binding, and comparative effects of allyl and propargyl groups on optical properties (2025-03-01)
Anti-ulcer activity of green synthesized selenium nanoparticles using Nigella sativa L. seed extract in rats (2025-01-01)
GC-MS/MS Analysis and Wound Repair Potential of Urtica dioica Essential Oil: In silico Modeling and In vivo Study in Rats (2025-01-01)
Synthesis, Molecular Docking And Anticancer Activity Of New Substituted Pyridine-1,2,3-Triazole Hybrid N-Glycosides Via Click Chemistry (2024-12-01)
Design, synthesis, biological evaluation, kinetic studies and molecular modeling of imidazo-isoxazole derivatives targeting both α-amylase and α-glucosidase inhibitors (2024-10-30)
Synthesis, optical properties, DNA, β-cyclodextrin interactions, and antioxidant evaluation of novel isoxazolidine derivative (ISoXD2): A multispectral and computational analysis (2024-07-30)
Synthesis, photophysical and docking studies of a novel isoxazolidine–benzimidazole hybrid and preliminary cytotoxic evaluation: Binding interactions with DNA and β-cyclodextrin (2026-12-15)
Identification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: Design, synthesis, in vitro and multiscale molecular modeling approaches (2024-02-29)
Synthesis, optical properties, DNA, β-cyclodextrin interaction, hydrogen isotope sensor and computational study of new enantiopure isoxazolidine derivative (ISoXD) (2024-02-29)
In Silico Design, Synthesis, and Evaluation of Novel Enantiopure Isoxazolidines as Promising Dual Inhibitors of α-Amylase and α-Glucosidase (2024-01-01)
Corrigendum to “Design, synthesis, biological evaluation and in silico studies of novel 1,2,3-triazole linked benzoxazine-2,4-dione conjugates as potent antimicrobial, antioxidant and anti-inflammatory agents” [Arab. J. Chem. 15(11) (2022) 104226](S1878535222005421)(10.1016/j.arabjc.2022.104226) (2023-09-01)
In Vitro and In Silico Evaluation of Antiproliferative Activity of New Isoxazolidine Derivatives Targeting EGFR: Design, Synthesis, Cell Cycle Analysis, and Apoptotic Inducers (2023-07-01)
GC/MS Profiling, Antibacterial, Anti-Quorum Sensing, and Antibiofilm Properties of Anethum graveolens L. Essential Oil: Molecular Docking Study and In-Silico ADME Profiling (2023-05-01)
Phytochemical profiling, antimicrobial, antibiofilm, insecticidal, and anti-leishmanial properties of aqueous extract from Juglans regia L. root bark: In vitro and in silico approaches (2023-01-01)
Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties (2023-01-01)
Mechanochemical promoted heterocycles: A solvent-free route to triazole carbohydrates as glycogen phosphorylase inhibitors (2022-12-01)
A Reversible Optical Sensor Film for Mercury Ions Discrimination Based on Isoxazolidine Derivative and Exhibiting pH Sensing (2022-11-01)
Multifunctional Derivatives of Spiropyrrolidine Tethered Indeno-Quinoxaline Heterocyclic Hybrids as Potent Antimicrobial, Antioxidant and Antidiabetic Agents: Design, Synthesis, In Vitro and In Silico Approaches (2022-11-01)
Design, synthesis, biological evaluation and in silico studies of novel 1,2,3-triazole linked benzoxazine-2,4-dione conjugates as potent antimicrobial, antioxidant and anti-inflammatory agents (2022-11-01)
Design, synthesis, in vitro anticancer and antimicrobial evaluation, SAR analysis, molecular docking and dynamic simulation of new pyrazoles, triazoles and pyridazines based isoxazole (2022-09-15)
Novel (2-Oxoindolin-3-ylidene)methyl)-1H-pyrazole and their fused derivatives: Design, synthesis, antimicrobial evaluation, DFT, chemical approach, in silico ADME and molecular docking studies (2022-09-15)
In Vitro and In Silico Screening of Anti-Vibrio spp., Antibiofilm, Antioxidant and Anti-Quorum Sensing Activities of Cuminum cyminum L. Volatile Oil (2022-09-01)
Synthesis and Characterization of Novel Isoxazolidine-Thiosemicarbazone Hybrid Derivatives as Precursor of Unnatural Amino acids (2022-09-01)
Phytochemical Profiling, Antimicrobial and α-Glucosidase Inhibitory Potential of Phenolic-Enriched Extracts of the Aerial Parts from Echium humile Desf.: In Vitro Combined with In Silico Approach (2022-05-01)
New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies (2022-04-15)
Preparation and characterization of ZnO nanoparticles incorporated by mechanical milling into cellulose for electrical insulator applications (2022-04-01)
GC-MS Profiling, Vibriocidal, Antioxidant, Antibiofilm, and Anti-Quorum Sensing Properties of Carum carvi L. Essential Oil: In Vitro and In Silico Approaches (2022-04-01)
Phytochemical Profiling of Allium subhirsutum L. Aqueous Extract with Antioxidant, Antimicrobial, Antibiofilm, and Anti-Quorum Sensing Properties: In Vitro and In Silico Studies (2022-02-01)
HPLC-MS Profiling, Antioxidant, Antimicrobial, Antidiabetic, and Cytotoxicity Activities of Arthrocnemum indicum (Willd.) Moq. Extracts (2022-01-01)
Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies (2022-01-01)
Toward a treatment of antibacterial and antifungal infections: Design, synthesis and in vitro activity of novel arylhydrazothiazolylsulfonamides analogues and their insight of DFT, docking and molecular dynamic simulations (2021-11-05)
Hplc/ms phytochemical profiling with antioxidant activities of echium humile desf. Extracts: Admet prediction and computational study targeting human peroxiredoxin 5 receptor (2021-11-01)
X-ray molecular structure characterization of a hexamethylenetetramine zinc(II) porphyrin complex, catalytic degradation of toluidine blue dye, experimental and statistical studies of adsorption isotherms (2021-11-01)
Tomatidine and patchouli alcohol as inhibitors of SARS-CoV-2 enzymes (3CLpro, PLpro and NSP15) by molecular docking and molecular dynamics simulations (2021-10-01)
Synthesis, Structure-Activity Relationship and in silico Studies of Novel Pyrazolothiazole and Thiazolopyridine Derivatives as Prospective Antimicrobial and Anticancer Agents (2021-08-20)
Antimicrobial, antioxidant, anti-acetylcholinesterase, antidiabetic, and pharmacokinetic properties of carum carvi l. And coriandrum sativum l. essential oils alone and in combination (2021-06-02)
Bioactivities and in silico study of Pergularia tomentosa L. phytochemicals as potent antimicrobial agents targeting type IIA topoisomerase, TyrRS, and Sap1 virulence proteins (2021-05-01)
Lc-esi/ms-phytochemical profiling with antioxidant, antibacterial, antifungal, antiviral and in silico pharmacological properties of algerian asphodelus tenuifolius (Cav.) organic extracts (2021-04-01)
New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis (2021-04-01)
Repurposing of anisomycin and oleandomycin as a potential anti-(SARS-CoV-2) virus targeting key enzymes using virtual computational approaches (2021-01-01)
Tripeptides from Allium subhirsitum L. extracts: Pharmacokinetics properties, toxicity prediction and in silico study against SARS-CoV-2 enzymes and pro-inflammatory proteins (2021-01-01)
Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular docking studies (2020-11-05)
Antioxidant activities of a new chemotype of piper cubeba L. Fruit essential oil (methyleugenol/eugenol): In silico molecular docking and admet studies (2020-11-01)
Hr-lcms-based metabolite profiling, antioxidant, and anticancer properties of teucrium polium l. Methanolic extract: Computational and in vitro study (2020-11-01)
Novel enantiopure isoxazolidine and C-alkyl imine oxide derivatives as potential hypoglycemic agents: Design, synthesis, dual inhibitors of α-amylase and α-glucosidase, ADMET and molecular docking study (2020-11-01)
Allium subhirsutum L. As a potential source of antioxidant and anticancer bioactive molecules: Hr-lcms phytochemical profiling, in vitro and in vivo pharmacological study (2020-10-01)
Design, synthesis ADMET and molecular docking of new imidazo[4,5-b]pyridine-5-thione derivatives as potential tyrosyl-tRNA synthetase inhibitors (2020-09-01)
Zinc(ii) triazole: Meso -arylsubstituted porphyrins for UV-visible chloride and bromide detection. Adsorption and catalytic degradation of malachite green dye (2020-06-12)
In vitro antimicrobial and α-glucosidase inhibitory potential of enantiopure cycloalkylglycine derivatives: Insights into their in silico pharmacokinetic, druglikeness, and medicinal chemistry properties (2020-06-01)
Multifunctional isoxazolidine derivatives as α-amylase and α-glucosidase inhibitors (2020-05-01)
Effect of the coordination of π-acceptor 4-cyanopyridine ligand on the structural and electronic properties of: Meso-tetra(para-methoxy) and meso-tetra(para-chlorophenyl) porphyrin cobalt(ii) coordination compounds. Application in the catalytic degradation of methylene blue dye (2020-02-01)
Synthesis, in vitro antimicrobial assessment, and computational investigation of pharmacokinetic and bioactivity properties of novel trifluoromethylated compounds using in silico ADME and toxicity prediction tools (2020-02-01)
Optical and photoelectronic properties of a new material: Optoelectronic application (2020-01-01)
Unprecedented Synthesis of 4-Ylidene (3 S)-3-hydroxy-1-aryl (alkyl)-pyrrolidine-2,5-diones Based on 1,3-Dipolar Cycloaddition of a Sugar-derived Nitrone to N-Substituted Maleimides (2019-05-24)
Synthesis and SPAR exploration of new semicarbazone-triazole hybrids in search of potent antioxidant, antibacterial and antifungal agents (2019-02-01)
Synthesis of New Porphyrin Complexes: Evaluations on Optical, Electrochemical, Electronic Properties and Application as an Optical Sensor (2019-01-31)
Design, synthesis, molecular properties and in vitro antioxidant and antibacterial potential of novel enantiopure isoxazolidine derivatives (2020-01-01)
Biological Activities Evaluation of Enantiopure Isoxazolidine Derivatives: In Vitro, In Vivo and In Silico Studies (2019-03-15)
Stereoselective synthesis of enantiopure N-substituted pyrrolidin-2,5-dione derivatives by 1,3-dipolar cycloaddition and assessment of their in vitro antioxidant and antibacterial activities (2017-01-01)
Crystal structure of (1S,2S,2'R,3a'S,5R)-2'-[(5-bromo-1H-indol-3-yl)methyl]-2-isopropyl-5,5'-dimethyldihydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-4'(5'H)-one (2016-08-01)
Crystal structure of 2-isopropyl-5,7'-dimethyl-1',3',3a',6',8a',8b'-hexahydrospiro[cyclohexane-1,6'-furo[3,4-d]imidazo[1,5-b]isoxazol]-8'(7'H)-one (2016-08-01)
A stereoselective method for the synthesis of enantiopure 3-substituted 4-hydroxyproline derivatives via 1,3-dipolar cycloadditions (2016-08-01)
Unprecedented 3-O-methyl-3-C-trifluoromethyl-d-ribono- (and l-lyxono)-γ-lactones synthesized by nucleophilic trifluoromethylation of d-hexose-derived cyclic ketones (2016-06-01)
Unexpected synthesis of aziridines under Cu(I) catalyzed Kinugasa conditions assisted by microwave irradiation (2016-03-01)
Unprecedented stereoselective synthesis of 3-methylisoxazolidine-5-aryl-1,2,4-oxadiazoles via 1,3-dipolar cycloaddition and study of their in vitro antioxidant activity (2016-01-01)
Synthesis of some isoxazolidine and isoxazoline derivatives using nitrone-derived (-)-menthone via 1,3-dipolar cycloaddition with alkenes, alkynes and cycloalkenes (2016-01-01)
Crystal structure of 5-chloromethyl-N-methyl-4-[(4-phenyl-1,2,3-triazol-1-yl)methyl]isoxazolidine-3-carboxamide (2016-01-01)
Novel routes to either racemic or enantiopure α-amino-(4-hydroxy-pyrrolidin-3-yl)acetic acid derivatives and biological evaluation of a new promising pharmacological scaffold (2015-05-31)
Stereoselective synthesis of enantiopure cycloalkylglycines by 1,3-dipolar cycloaddition of a chiral nitrone to cycloalkenes (2014-01-01)
A cycloaddition-cyclization combined approach to enantiopure 3-glycinyl-4-hydroxypyrrolidines and 3-substituted 4-hydroxyprolines (2014-01-01)
Stereoselective synthesis of 1,2,3-triazolyl-functionalized isoxazolidines, via two consecutive 1,3-dipolar cycloadditions, as precursors of unnatural amino acids (2013-04-10)
1,3-Dipolar cycloaddition of a chiral nitrone to (E)-1,4-dichloro-2-butene: A new efficient synthesis of (2S,3S,4R)-4-hydroxyisoleucine (2012-06-06)
Cycloaddition of a chiral nitrone to allylic motifs: An access to enantiopure sugar-based amino acids displaying a stable glycosidic bond and to 4(S)-4-hydroxy-l-ornithine (2012-02-11)
Study of the regio-and stereoselectivity of [3+2] cycloaddition of nitrile oxides to various racemic 3-acyloxy and 3-hydroxybut-1-enes (2012-02-01)
Inhibition of HSP90 with pochoximes: SAR and structure-based insights (2009-11-23)
Multi-step synthesis and biological evaluation of analogues of insulin secretagogue (2S,3R,4S)-4-hydroxyisoleucine (2009-01-01)
Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor (2008-05-26)
Analogues of insulin secretagogue (2S,3R,4S)-4-hydroxyisoleucine: synthesis by 1,3-dipolar cycloaddition reactions of chiral nitrones to alkenes (2008-05-16)
C-glycosyl amino-substituted hydro- and benzoquinones: Synthesis and preliminary biological evaluation (2007-11-16)
New synthetic routes toward enantiopure (2S,3R,4R)-4-hydroxyisoleucine by 1,3-dipolar cycloaddition of a chiral nitrone to C4 alkenes (2007-11-02)
Synthesis of semicyclic dienes by modified Julia olefination of vinyl sulfones derived from carbohydrates (2007-10-01)
(1S,2R,2′S,3′aS,5R)-2′-[(1S)-1-hydroxyethyl] -2-isopropyl-5,5′-dimethyl-3′,3′a-dihydro-2′H-spiro- [cyclohexane-1,6′-imidazo[1,5-b]isoxazol]-4′(5′H)-one (2007-02-28)
(1S,2R,2′S,3′aS,5R)-2′-[(1R)-1-hydroxyethyl] -2-isopropyl-5,5′-dimethyl-3′,3′a-dihydro-2′H-spiro- [cyclohexane-1,6′-imidazo[1,5-b]isoxazol]-4′(5′H)-one (2007-02-28)
Cycloadditions of chiral nitrones to racemic 3-substituted butenes: A direct access with kinetic resolution to enantiopure dihydroxylated amino acids (2006-12-01)
Ginger essential oil as a green nanotechnology agent: Composition, nanoparticle synthesis, and biomedical applications (2025-01-01)

المواد التدريسية

كيمياء عامة كيم 202
كيمياء عضوية متقدمة كيم 640
أطياف كيم 442
كيمياء عضوية كيم 249
كيمياء عضوية 2. كيم340

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أعضاء هيئة التدريس

المحتوى

قيس ابراهيم محمد الصغير العوادي

أستاذ

كلية العلوم،

قسم الكيمياء

البيانات الشخصية

المؤهلات العلمية

الاهتمامات البحثية

الأبحاث المنشورة

المواد التدريسية

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