فيزول عزام محمد عثمان - جامعة القصيم

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مسجل لدى هيئة الحكومة الرقمية برقم: 20250413538

أعضاء هيئة التدريس

صورة عضو هيئة التدريس

فيزول عزام محمد عثمان

أستاذ مشارك

كلية الصيدلة،

قسم الكيمياء الطبية والعقاقير

البيانات الشخصية

المؤهلات العلمية

PhD

الاهتمامات البحثية

DFT Calculations
Computational Chemistry
Medicinal Chemistry
Molecular Dynamics Simulation
Computer-Aided Drug Design (CADD)

الأبحاث المنشورة

Targeting oxidative stress component in the therapeutics of epilepsy (2012-01-01)
Combating oxidative stress in epilepsy: design, synthesis, quantum chemical studies and anticonvulsant evaluation of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl … (2010-01-01)
Degree-based topological indices and polynomials of hyaluronic acid-curcumin conjugates (2020-01-01)
Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound (2020-01-01)
Anti-endotoxin effects of terpenoids fraction from Hygrophila auriculata in lipopolysaccharide-induced septic shock in rats (2015-01-01)
Design and synthesis of pyrazole–pyrazoline hybrids as cancer‐associated selective COX‐2 inhibitors (2020-01-01)
Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: A computational investigation (2014-01-01)
Synthesis of some urea and thiourea derivatives of 3-phenyl/ethyl-2-thioxo-2, 3-dihydrothiazolo [4, 5-d] pyrimidine and their antagonistic effects on haloperidol-induced … (2009-01-01)
Design, synthesis and anti-Parkinsonian evaluation of 3-alkyl/aryl-8-(furan-2-yl) thiazolo [5, 4-e][1, 2, 4] triazolo [1, 5-c] pyrimidine-2 (3 H)-thiones against neuroleptic … (2010-01-01)
Rutin as promising drug for the treatment of Parkinson’s disease: an assessment of MAO-B inhibitory potential by docking, molecular dynamics and DFT studies (2019-01-01)
Chemotherapy-induced cardiotoxicity: a new perspective on the role of Digoxin, ATG7 activators, Resveratrol, and herbal drugs (2023-01-01)
Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X2 and actinomycin D produced by novel Streptomyces … (2021-01-01)
NSAIDs as potential treatment option for preventing amyloid β toxicity in Alzheimer’s disease: an investigation by docking, molecular dynamics, and DFT studies (2018-01-01)
Synthesis of some novel N 4-(naphtha [1, 2-d] thiazol-2-yl) semicarbazides as potential anticonvulsants (2009-01-01)
Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2′-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial … (2007-01-01)
Topological indices and QSPR/QSAR analysis of some antiviral drugs being investigated for the treatment of COVID‐19 patients (2020-01-01)
An in-silico analysis of ivermectin interaction with potential SARS-CoV-2 targets and host nuclear importin α (2022-01-01)
Molecular Docking and Prediction of Pharmacokinetic Properties of Dual Mechanism Drugs that Block MAO-B and Adenosine A2A Receptors for the Treatment of Parkinson's Disease (2012-01-01)
Adenosine A2A receptor antagonists as novel anti-Parkinsonian agents: a review of structure-activity relationships (2009-01-01)
Targeting SARS-CoV-2 main protease by teicoplanin: a mechanistic insight by docking, MM/GBSA and molecular dynamics simulation (2021-01-01)
The Dynamic Role of Curcumin in Mitigating Human Illnesses: Recent Advances in Therapeutic Applications (2024-01-01)
Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes (2023-01-01)
Molecular interaction studies of green tea catechins as multitarget drug candidates for the treatment of Parkinson’s disease: computational and structural insights (2015-01-01)
Inclusion complex of clausenidin with hydroxypropyl-β-cyclodextrin: Improved physicochemical properties and anti-colon cancer activity (2021-01-01)
Nano-engineered nerolidol loaded lipid carrier delivery system attenuates cyclophosphamide neurotoxicity–Probable role of NLRP3 inflammasome and caspase-1 (2020-01-01)
Molecular docking studies of 1-(substituted phenyl)-3-(naphtha [1,2-d] thiazol-2-yl) urea/thiourea derivatives with human adenosine A2A receptor (2011-01-01)
Elucidation of Teicoplanin Interactions with Drug Targets Related to COVID-19 (2021-01-01)
Ester Prodrugs of Ketoprofen: Synthesis, in vitro Stability and in vivo Biological Evaluation, and In Silico Comparative Docking Studies against COX-1 and COX-2. (2016-01-01)
Safety, Stability, and Therapeutic Efficacy of Long-Circulating TQ-Incorporated Liposomes: Implication in the Treatment of Lung Cancer (2022-01-01)
Oxasetin from Lophiostoma sp. of the Baltic Sea: identification, in silico binding mode prediction and antibacterial evaluation against fish pathogenic bacteria. (2013-01-01)
Structure-based design, synthesis and molecular modeling studies of thiazolyl urea derivatives as novel anti-Parkinsonian agents (2012-01-01)
Synthesis of quinoline attached-furan-2 (3H)-ones having anti-inflammatory and antibacterial properties with reduced gastro-intestinal toxicity and lipid peroxidation (2011-01-01)
Anti-inflammatory, analgesic and molecular docking studies of Lanostanoic acid 3-O-α-D-glycopyranoside isolated from Helichrysum stoechas (2020-01-01)
In Vitro and In Silico Approaches for the Antileishmanial Activity Evaluations of Actinomycins Isolated from Novel Streptomyces smyrnaeus Strain UKAQ_23 (2021-01-01)
Current Status of Novel Pyridine Fused Derivatives as Anticancer Agents: An Insight into Future Perspectives and Structure Activity Relationship (SAR) (2021-01-01)
Zerumbone binding to estrogen receptors: an in-silico investigation (2018-01-01)
Structure-based design, synthesis, molecular docking, and biological activities of 2-(3-benzoylphenyl) propanoic acid derivatives as dual mechanism drugs (2012-01-01)
On Ve‐Degree and Ev‐Degree Topological Properties of Hyaluronic Acid‐Anticancer Drug Conjugates with QSPR (2021-01-01)
Zerumbone Induces Apoptosis in Breast Cancer Cells by Targeting αvβ3 Integrin upon Co-Administration with TP5-iRGD Peptide (2019-01-01)
Structure-based design, synthesis, and molecular modeling studies of 1-(benzo [d] thiazol-2-yl)-3-(substituted aryl) urea derivatives as novel anti-Parkinsonian agents (2012-01-01)
Synthesis, DFT analyses, antiproliferative activity, and molecular docking studies of curcumin analogues (2022-01-01)
Experimental and theoretical insights on chemopreventive effect of the liposomal thymoquinone against benzo [a] pyrene-induced lung cancer in Swiss albino mice (2022-01-01)
Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2, 4-thiazolidinediones as partial PPAR-γ agonists (2023-01-01)
Lipid-Based Nanoparticle Formulation of Diallyl Trisulfide Chemosensitizes the Growth Inhibitory Activity of Doxorubicin in Colorectal Cancer Model: A Novel In Vitro, In Vivo … (2022-01-01)
Effect of thymoquinone on high fat diet and STZ‐induced experimental type 2 diabetes: A mechanistic insight by in vivo and in silico studies (2021-01-01)
Synthesis of some urea and thiourea derivatives of naphtha [1, 2-d] thiazol-2-amine as anti-Parkinsonian agents that cause neuroprotection against haloperidol-induced oxidative … (2009-01-01)
New Paradigms of Old Psychedelics in Schizophrenia (2022-01-01)
Development and validation of a novel UPLC-MS/MS method for quantification of delafloxacin in plasma and aqueous humour for pharmacokinetic analyses (2020-01-01)
Effectiveness of estrogen and its derivatives over dexamethasone in the treatment of COVID-19 (2024-01-01)
The Enhanced Affinity of WRKY Reinforces Drought Tolerance in Solanum lycopersicum L.: An Innovative Bioinformatics Study (2023-01-01)
Liposomal Ellagic Acid Alleviates Cyclophosphamide-Induced Toxicity and Eliminates the Systemic Cryptococcus neoformans Infection in Leukopenic Mice (2021-01-01)
In silico and in vitro studies on the inhibition of laccase activity by Ellagic acid: Implications in drug designing for the treatment of Cryptococcal infections (2022-01-01)
The Effect of Liposomal Diallyl Disulfide and Oxaliplatin on Proliferation of Colorectal Cancer Cells: In Vitro and In Silico Analysis (2022-01-01)
Eucalyptus-derived essential oils alleviate microbes and modulate inflammation by suppressing superoxide and elastase release (2023-01-01)
Synthesis, characterization and biological activity of polyketones (2013-01-01)
Neuroprotective effect of naphtha [1, 2-d] thiazol-2-amine in an animal model of Parkinson's disease (2009-01-01)
Identification of potential inhibitors of HER2 targeting breast cancer—a structure-based drug design approach (2024-01-01)
Structural, functional, molecular, and biological evaluation of novel triterpenoids isolated from Helichrysum stoechas (L.) Moench. Collected from Mediterranean Sea bank … (2022-01-01)
Synthesis and biological studies of oxoquinolines: Experimental and theoretical investigations (2022-01-01)
Synthesis, and biological evaluation of some 4-thiazolidinones (2004-01-01)
Formulation, In Vitro and In Silico Evaluations of Anise (Pimpinella anisum L.) Essential Oil Emulgel with Improved Antimicrobial Effects (2023-01-01)
Therapeutic potential of free radical scavengers in neurological disorders (2010-01-01)
Toward the Discovery of a Novel Class of Leads for High Altitude Disorders by Virtual Screening and Molecular Dynamics Approaches Targeting Carbonic Anhydrase (2022-01-01)
An Insight into the Structural Requirements and Pharmacophore Identification of Carbonic Anhydrase Inhibitors to Combat Oxidative Stress at High Altitudes: An In-Silico Approach (2022-01-01)
Ginger Components as Anti‐Alzheimer Drugs: Focus on Drug Design (2017-01-01)
Synthesis and characterization of new unsaturated polyesters containing cyclopentapyrazoline moiety in the main chain (2010-01-01)
Synthesis and antimicrobial activities of some 5-(4'-pyridyl)-4-substituted benzylideneamino-3-mercapto (4H)-1, 2, 4-triazoles (2004-01-01)
In vitro and in silico evaluations of actinomycin X2and actinomycin D as potent anti-tuberculosis agents (2023-01-01)
A Dig Deep to Scout the Pharmacological and Clinical Facet of Garlic (Allium sativum) (2022-01-01)
Host Cell and SARS-CoV-2-Associated Molecular Structures and Factors as Potential Therapeutic Targets (2021-01-01)
A simple validated HPTLC method for the analysis of flavonoids and molecular docking studies of novel tri-terpenoid glycoside isolated from Carya illinoinensis bark with … (2022-01-01)
An in-silico approach to target multiple proteins involved in anti-microbial resistance using natural compounds produced by wild mushrooms (2024-01-01)
Exploring cyclopropylamine containing cyanopyrimidines as LSD1 inhibitors: Design, synthesis, ADMET, MD analysis and anticancer activity profiling (2024-01-01)
In Silico investigation of the structural requirements for the AMPA receptor antagonism by quinoxaline derivatives (2013-01-01)
Adsorption of methotrexate on hyaluronic acid: A comparative DFT and molecular dynamics simulation insights (2024-01-01)
An insight into the implications of estrogen deficiency and transforming growth factor β in antiepileptic drugs-induced bone loss (2021-01-01)
Design, molecular docking and MD simulation of novel estradiol-pyrimidine analogues as potential inhibitors of Mpro and ACE2 for COVID-19 (2024-01-01)
Development and Evaluation of Novel Encapsulated Isoeugenol-Liposomal Gel Carrier System for Methicillin-Resistant Staphylococcus aureus (2023-01-01)
Structure and electronic properties of the HA-CUR conjugate: An insight from the DFT perspective (2022-01-01)
Targeting tubulin protein by novel 3, 5-disubstituted-1, 2, 4-triazole analogues as anticancer agents: Design, synthesis, in-vitro, and in-silico studies (2025-01-01)
Insights into the Therapeutic Targets and Molecular Mechanisms of Eruca sativa Against Colorectal Cancer: An Integrated Approach Combining Network … (2025-01-01)
A structure-based drug design approach for the identification of antiviral compounds targeting the chikungunya virus RdRp protein (2024-01-01)
Deciphering Campylobacter jejuni DsbA1 protein dynamics in the presence of anti-virulent compounds: a multi-pronged computer-aided approach (2025-01-01)
Solvent-free synthesis, anticancer activity and in-silico studies of 7-hydroxy-4-methylquinolin-2 (1H)-one analogues (2024-01-01)
The role of Aedes aegypti in inducing/aggravating IgE-mediated allergic airway disease: extensive computational studies for identification of allergenic proteins (2024-01-01)
Dynamic and thermodynamic impact of L94A, W100A, and W100L mutations on the D2 dopamine receptor bound to risperidone (2022-01-01)
Synthesis and characterization of polyesters based on diethylketone moiety (2014-01-01)
Mechanistic insights into novel cyano-pyrimidine pendant chalcone derivatives as LSD1 inhibitors by docking, ADMET, MM/GBSA, and molecular dynamics simulation (2025-01-01)
Non-Beta-Blocker Medications with Beta-Blocker Like Properties: A Systematic Review of Side Effects (2025-01-01)
An immuno-informatics approach for annotation of hypothetical proteins and multi-epitope vaccine designed against the Mpox virus (2024-01-01)
Microsecond MD Simulations to Explore the Structural and Energetic Differences between the Human RXRα-PPARγ vs. RXRα-PPARγ-DNA (2022-01-01)
Nigella sativa oil alleviates doxorubicin-induced cardiomyopathy and neurobehavioral changes in mice: In vivo: and: in-silico: study (2022-01-01)
Targeting SARS-CoV-2 main protease by teicoplanin: a mechanistic insight by in silico studies (2020-01-01)
Targeting Mitochondrial Drp1 Dynamics in Neurodegenerative Diseases: A Comprehensive Drug Design Approach Using AutoDock Vina‐GPU, DFT, and Molecular Dynamics Simulations (2025-01-01)
Isolation, Characterization, and Anti‐Inflammatory Effects of β‐Sitosterol‐β‐D‐Glucoside from Hygrophila auriculata: Experimental Validation, Molecular Docking, and Molecular … (2024-01-01)
Green Synthesis of Oxoquinoline-1 (2H)-Carboxamide as Antiproliferative and Antioxidant Agents: An Experimental and In-Silico Approach to High Altitude Related Disorders (2022-01-01)
Advancement in chemistry and recent medicinal importance of oxadiazole (2021-01-01)
Monotherapy vs combination therapy evaluation of FDA-approved TKIs targeting PDGFR for the treatment of thyroid cancer (2026-01-01)
Cracking the Sulfur Code: Garlic Bioactive Molecules as Multi-Target Blueprints for Drug Discovery (2025-01-01)
Thiazolidinedione‐Pyrimidine Hybrid as Potential Antidiabetic Agents and Their Cardioprotective Effect (2025-01-01)
Preclinical and Molecular Docking Insights into the Chemopreventive Role of Fenugreek Seed Extract in a Murine Model of Colorectal Cancer (2025-01-01)
The Structural, Biological, and In-Silico Profiling of Novel Capryloyl Tetra-Glucoside and Aliphatic Ester Constituents from the Abutilon indicum Offers New … (2022-01-01)
Synthesis and characterization of liquid crystalline poly (ether-ketone) s containing 1-benzyl-4-piperidone moiety as a pendent group (2022-01-01)
Pharmacological Recognition of Urea Derivatives in Brain Disorders (2012-01-01)
Modular Approach to In Silico Antiviral Multitargets Inhibitor: Molecular Dockings, Dynamics, Principal Component Analysis, Clustering, and Energy Landscape (2026-01-01)
Arugula-derived isothiocyanates as novel agents for a potential regulator of AKR1B10 protein in breast cancer: an integrated transcriptomic and molecular docking approach (2025-01-01)
Computational study of chalcone-cyanopyrimidine hybrids as LSD1 inhibitors: Assessing the influence of FAD on binding affinity and inhibition (2025-01-01)
Structural and Magneto-Optical Study on the Tetrahedrally Configured [CoCl2(1-allylimidazole)2] and Molecular Docking to Hypoxia-Inducible Factor-1α (2025-01-01)
In silico optimization of pyrimidine-thiazolidinedione hybrids targeting PPAR-γ: Design, docking, MM-GBSA, ADMET, and MD simulation (2025-01-01)
Identifying a novel class of lead compounds for monoacylglycerol lipase inhibition: an integrated computational study (2025-01-01)
Isoniazid Derivatives as Potential Lipoxygenase‐15 Inhibitors: In‐vitro and In‐silico Studies (2024-01-01)
Cytokines as Potential Therapeutic Targets (2006-01-01)

المواد التدريسية

General Chemistry
Organic Chemistry
Medicinal Chemistry
Computer-Aided Drug Design and Discovery