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Colleges

Integrated drug therapy: Nervous system

Course Description: Integrated Pharmacotherapy: Nervous System is an advanced, integrated curriculum that takes an organ-based approach. It is typically taught in the advanced years of pharmacy colleges, such as the Doctor of Pharmacy (PharmD) program. The course aims to provide the knowledge and skills necessary to safely and effectively manage conditions related to the nervous system, focusing on the following integrated aspects: Nervous System Disorders: In-depth focus on central and peripheral nervous system diseases, including neurological and psychiatric disorders. Knowledge Integration: The course integrates several foundational sciences to fully understand the condition and develop a therapeutic plan, such as: Physiology and Pathophysiology to understand the origin of the disease. Pharmacology and Medicinal Chemistry to understand drug mechanisms of action. Pharmacokinetics to select the appropriate dosage for each patient. Clinical Pharmacy Care: The course enhances clinical pharmacist skills, such as patient assessment, treatment monitoring, and advising patients and other healthcare teams, to ensure safe and effective achievement of desired therapeutic outcomes.
Credit hours: 4
Prerequisites: 251 PHP
Objectives of the course :

Understanding the Scientific Foundations
Provision of a solid foundation for understanding the physiology and pathophysiology of the nervous system, and their relationship with the rational design of drugs used in treatment.

 

Evidence-based treatment decision-making
- Develop the student's ability to evaluate and compare available treatment options for various nervous system conditions, and to select the most appropriate based on individual patient characteristics and the latest scientific evidence.

Design and Management of Treatment Plans
– Enable the student to design integrated and safe drug therapy plans for patients with nervous system disorders (central and peripheral), with the ability to anticipate side effects, adjust dosages, and monitor outcomes.

Enhancing Clinical and Pharmaceutical Skills
– Applying principles of pharmacokinetics and therapeutic drug monitoring (TDM), and analyzing disease states and laboratory data to achieve optimal drug utilization.

Integrating into the Integrated Care Team:
Preparing the student to work as part of a multidisciplinary health team in managing neurological conditions, taking responsibility and communicating effectively with patients and caregivers.

Understanding the mechanisms of action of drugs and drug classes, including their chemical composition, drug interactions, and active groups.

Course outputs :

Knowledge & Understanding
Pathophysiology of Central and Peripheral Nervous System Disorders (e.g., Epilepsy, Parkinson's Disease, Depression, Schizophrenia, Neuropathic Pain) and their Link to Potential Drug Targets.

 

Linking the chemical structure of drugs used to treat nervous system diseases to their mechanism of action (Structure-Activity Relationship - SAR), and its effect on their selectivity and toxicity.

Pharmacokinetics (absorption, distribution, metabolism, excretion) of major neuroleptics, and interpretation of how disease states and physiological changes (age, pregnancy, renal/hepatic insufficiency) affect them.

Interpretation of the relationship between different pharmaceutical dosage forms (e.g., extended-release tablets, injectable solutions, transdermal patches) and drug pharmacokinetics in the body, and how to choose the appropriate dosage form for a patient's neurological condition.

Second: Skills
Integrated clinical case analysis of the neurological patient through the collection and interpretation of clinical, laboratory, and pharmacological data, to reach an accurate diagnosis of their potential drug-related problems.

Design an evidence-based pharmacologic treatment plan including drug selection, initial dose determination, and route of administration, taking into account the patient's individual characteristics (age, weight, liver and kidney function, concomitant medications).

Adjust dosing regimens using pharmacokinetic equations and specialized computer programs (e.g., TDM programs for phenytoin, carbamazepine, valproic acid) to achieve optimal therapeutic concentrations and avoid toxicity.

Applying professional communication skills in providing pharmaceutical consultation to neurotic patients and their caregivers, as well as in discussing the treatment plan with a multidisciplinary health team.

Third: Values, Autonomy & Responsibility
Adhering to ethical and professional principles when dealing with neurological patients, especially in cases of drug sensitivity, poor treatment adherence, or the need to use controlled and monitored medications.

Take responsibility for continuous self-learning by reviewing recent scientific sources (such as updated treatment guidelines and new drug safety experiences) to advance practice in the field of neurology.

Demonstrate leadership and teamwork when participating in healthcare teams responsible for managing complex neurological conditions (e.g., refractory epilepsy, advanced Parkinson's disease).

Additional information:

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