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Chemistry and Radiobiology

Course Description: This course links the chemical and biological foundations of radiation action to their clinical applications. It covers radiation chemistry—free radical formation, water radiolysis, and indirect effects—along with the radiobiology of cells, tissues, and organs, preparing the student to infer dose-response relationships, risk versus benefit in the use of radiation, and the sources of information used to assess these risks.
Credits: 2
Prerequisites: HLTH244
Objectives of the course :

• Description of the chemistry of radiation absorption and radiolysis of water, and the formation of free radicals.
• Interpretation of direct and indirect action and mechanisms of DNA damage and repair.
• Description of the cell cycle and radiosensitivity of its phases, and the main dose-response models.
• Comparison of radiation sensitivity of different organs and the role of radiation protectors and sensitizers.
Understand deterministic thresholds and acute radiogenic syndromes, and the principles of radiation protection.

Course outputs :

Knowledge and understanding:
• Defining the chemical pathways by which radiation deposits energy and produces biological effects.
• Identification of radiation types, their relative biological effectiveness, and the chemistry of indirect action.
Skills:
• Evaluating dose-response relationships and the chemistry of free radical scavengers, protectors, and radiosensitizers.
• Understanding the risk versus benefit of using radiation and sources of information for assessing these risks.
Values:
• Recognize the responsibility of radiation protection for radiographers and appropriately communicate risks to patients.

Additional information:
  • Last update: 2026-06-24

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