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Pharmacokinetics of the drug

Course Description: This course introduces the fundamental principles of pharmacokinetics, the quantitative study of drug absorption, distribution, metabolism, and excretion (ADME). Students learn to apply compartmental and non-compartmental models to calculate key pharmacokinetic parameters such as clearance and volume of distribution. The course also focuses on employing these principles to optimize therapeutic dosing regimens, predict drug concentrations, and differentiate between linear and non-linear pharmacokinetics. The course emphasizes the clinical application of these principles.
Credits: 2
Prerequisites: PHT 221
Objectives of the course :

Building efficiency in determining key pharmacokinetic parameters from experimental and clinical data, and enhancing quantitative thinking to predict drug behavior using compartmental models and mathematical principles.
Acquiring clinical problem-solving skills by applying pharmacokinetic principles to design the most suitable drug dosing regimen for each patient, whether for drugs that follow linear or non-linear kinetics.
Explanation of pharmacokinetics principles for drugs following linear or nonlinear kinetics, including clinical implications for dosing and therapeutic drug monitoring.

Course outputs :

Knowledge and understanding:
Describe how absorption, distribution, metabolism, and excretion influence drug concentration-time curves and overall drug exposure.
Description of Pharmacokinetic Models and Their Applications.
Distinguishing between linear and nonlinear pharmacokinetics and understanding their practical implications.
Skills:
Calculation of kinetic parameters (linear and non-linear) using data analysis and interpretation (e.g., graph, Area Under the Curve (AUC), slopes, and curve fitting).
Design and justification of optimal drug dosage regimens using different pharmacokinetic models.
Predicting drug concentrations and steady state behavior using pharmacokinetic models.
Values, autonomy, and responsibility:
Demonstrate leadership skills, accountability, and responsibility-taking within the team in diverse contexts.
Demonstrate integrity, reliability, trustworthiness, self-awareness, and entrepreneurial potential in diverse contexts.

Additional information:
  • Last updated: 2026-05-12

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