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Principles of Pharmaceutical Chemistry

Course Description: This course introduces students to the medicinal chemistry of drugs, with a particular focus on pharmacokinetic, pharmacodynamic, and physicochemical properties and their relationship to biological activity. The course discusses the influence of chemical structure on drug interactions with various cellular targets and explains in detail the process of drug metabolism and factors affecting it. The course also introduces students to the fundamental principles of drug discovery, development, and design, and covers drug synthesis, identification, and analysis.
Credit hours: 3
Prerequisites: 121 PHC
Objectives of the course :

Understanding the relationship between the biological activity and the physical and chemical properties of a drug molecule.
• Understanding the process of metabolism and the factors involved in drug metabolism.
The modern drug discovery process and the elements that govern it.

Course outputs :

• Describe how the medication works at the molecular level.
• Demonstrate the ability to understand how to implement a rational approach to drug design.
Description and linkage between Structure-Activity Relationships (SAR) and Quantitative Structure-Activity Relationships (QSAR).
• Describe drug sources.
• Explain the basic concept of drug design and discovery.
Metabolic process estimation and factors involved in drug metabolism and their impact on metabolic drug design.
Explanation of the relationships between the physical and chemical properties of a drug, its prodrug, and their biological activity.
• Preparing some important intermediate and pharmaceutical compounds, as well as some basic laboratory experiments related to computer-aided drug design and drug metabolism. Identify drug sources.
• Drug design and discovery.
• Determine the relationships between the physical and chemical properties of a drug and the drug's functions at the molecular level.

Additional information:
  • Last updated: 2026-06-10

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